Immunocompetence inHydra: Epithelial cells recognize self-nonself and react against it

From Self to Nonself: The Nonself Theory

The maintenance/strength of self is a very core concept in Western psychology and is particularly relevant to egoism, a process that draws on the hedonic principle in pursuit of desires. Contrary to this and based on Buddhism, a nonself-cultivating process aims to minimize or extinguish the self and avoid desires, leading to egolessness or selflessness. The purpose of this paper is to present t...

Tangeretin protects renal tubular epithelial cells against experimental cisplatin toxicity

Objective(s): Cisplatin is an effective antineoplastic agent; its clinical utility, however, is limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective effects of tangeretin, a citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced renal toxicity of rats.Materials and Methods: Tangeretin was injected intra...

Different Mechanisms and Reject Allogeneic Nonself In Vivo via Innate NK Cells and Macrophages Recognize

Vegetative Self and Nonself Recognition in Fungi

The concepts of self and nonself have been a subject of much study and discussion in biology and philosophy. A signifi cant volume of research on the subject has answered some but also generated many more questions. What defi nes self? What mechanisms control self and nonself recognition? What is the purpose of such a recognition system? A product of the post-World War II early immunology movem...

Human intestinal Vdelta1+ lymphocytes recognize tumor cells of epithelial origin

gammadelta T cells can be grouped into discrete subsets based upon their expression of T cell receptor (TCR) variable (V) region families, their tissue distribution, and their specificity. Vdelta2+ T cells constitute the majority of gammadelta T cells in peripheral blood whereas Vdelta1+T cells reside preferentially in skin epithelium and in the intestine. gammadelta T cells are envisioned as f...